![]() In recent years, leukaemia molecular studies – as well as other types of cancer – have focused on molecular analysis with only one data layer, which provided a partial vision but did not allow researchers to create a precise map on the functions of the genome. Any queries (other than missing content) should be directed to the corresponding author for the article.Scientists generate an atlas of the human genome using stem cells… Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Table S6 Comparison of ROH hotspots found in sheep populations in different studies based on the ovine genome assembly 3.1. Table S5 Results of the functional classification with DAVID of genes mapping to putative ROH hotspots in 11 Spanish sheep breeds, using homo Sapiens as background. ![]() Table S4 Genes mapping into ROH hotspots in 11 Spanish sheep breeds.Īge1283-TableS5.pdfPDF document, 219.2 KB Table S3 Most common runs of homozygosity identified in11 Spanish sheep breeds. Table S2 Expected and observed heterozygosities and pairwise F ST values amongst 32 populations from Africa, Europe, Middle East and Oceania. Table S1 Breeding purpose of 11 Spanish sheep breeds. It can be seen that at K = 33 the cross-validation error is minimized.įigure S3 admixture analysis (K = 33) of 11 Spanish sheep breeds and reference populations from Europe, North Africa, Central Afric and Near East.įigure S4 admixture analysis ( K = 2–37) of 11 Spanish sheep breeds and reference populations from Europe, North Africa, Central Africa and Near East.įigure S5 A reduced view of Fig. 2 focused on sheep with less than 50 ROH and less than 300 Mb of total ROH coverage. The low levels of homozygosity observed in the 11 Spanish sheep under analysis might be due to their extensive management and the high number of small to medium farms.įigure S1 Weighted principal component analysis of 11 Spanish sheep breeds and reference populations from Europe.įigure S2 Plot of admixture cross-validation error from K = 2 through K = 37. Moreover, the frequencies of very long ROH (>30 Mb) are very low, and the inbreeding coefficients ( F ROH) are generally small ( F ROH < 0.10), ranging from 0.008 (Rasa Aragonesa) to 0.086 (Canaria de Pelo). Our analysis has also demonstrated that, with few exceptions, the genomes of Spanish sheep harbor fewer than 50 runs of homozygosity (ROH) with a total length of less than 350 Mb. ![]() ![]() By using Ovine SNP50 BeadChip data retrieved from previous publications, we have found that the majority of studied Spanish ovine breeds have close genetic relatedness with other European populations the one exception is the Canaria de Pelo breed, which is similar to North African breeds. The main goal of our study was to investigate the homozygosity patterns of 11 Spanish ovine breeds and to elucidate the relationship of these Spanish breeds with reference populations from Europe, Africa and the Near East. Such a demographic reduction might have caused an increase in homozygosity and inbreeding, thus limiting the viability of local breeds with excellent adaptations to harsh ecosystems. The population of Spanish sheep has decreased from 24 to 15 million heads in the last 75 years due to multiple social and economic factors. ![]()
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